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 In the current study, 17 patients (10 of whom had mesothelioma) received two injected doses of the therapy, given either one or two weeks apart Avi Dvd Burner 2008 5 1 0 22. Seven of the 17 mesothelioma patients in the study survived for more than 18 months. Through a process of continual genetic evolution a cell requires new phenotypes able to proliferate, invade, disseminate throughout the body, escape immune surveillance and resist treatment.  "It works in a variety of ways, some of which we have fully to elucidate," Dr. Avi Dvd Burner 2008 5 1 0 22 - Even the best treatment available â€" a combination of surgery, chemotherapy, and radiation â€" does little to prolong patients' survival. Avi Dvd Burner 2008 5 1 0 22 - Because mesothelioma is often diagnosed when the cancer has already spread, patients are given an average survival time of just one year. Avi Dvd Burner 2008 5 1 0 22 - Most of the patients tolerated the treatment well. Only one patient had a serious side effect. Avi Dvd Burner 2008 5 1 0 22 - Using computed tomography (CT) scans and PET imaging, the researchers found that one patient had a partial response, the disease stabilized in four patients, and two patients had no measurable disease after treatment. Avi Dvd Burner 2008 5 1 0 22 - However, some people inherit mutations in the germline (the gamets and their precursors). Avi Dvd Burner 2008 5 1 0 22 - Two patients in the study had dramatic responses to the treatment, and in four others the disease stabilized. Avi Dvd Burner 2008 5 1 0 22 -  Cancer results from an accumulation of multiple genetic alterations that either inhibit or enhance normal cellular processes. Avi Dvd Burner 2008 5 1 0 22 - One of the premises for the study of relatively rare inherited cancers is the assumption that understanding the molecular basis of these malignancies will result in better understanding and treatment strategies of the more common malignancies. Sterman to investigate whether repeat doses of this treatment might further increase the response. "We can only administer doses in a very small time window because the body produces antibodies to the virus and it hampers delivery," says Dr. Many genetic alterations have been recognized in human tumors.  One of the treatment avenues being studied is gene therapy, in which doctors use a vector (typically a virus) to carry a specific gene into the body Avi Dvd Burner 2008 5 1 0 22. Avi Dvd Burner 2008 5 1 0 22 - Inherited or genetic forms of cancer may be due to mutations in genes that directly control cell growth or apoptosis (1). While this has not yet resulted in new therapies, the management at diagnosis of many patients with an inherited predisposition has been radically altered. Sterman, MD, Associate Professor of Medicine at the University of Pennsylvania Medical Center Avi Dvd Burner 2008 5 1 0 22. Avi Dvd Burner 2008 5 1 0 22 -  The gene transfers were successful, and most of the patients in the study demonstrated an immune response following the treatment. Avi Dvd Burner 2008 5 1 0 22 - Some of these confer a survival advantage and hence lead to clonally expansion of the founder cell. Avi Dvd Burner 2008 5 1 0 22 - The authors believe this lack of additional response is due to the body's natural reaction to the viral vector. Thus, a working knowledge of cancer genetics will allow the clinician not only to appropriately manage patients, but also to comprehend the major advances in the field of oncology (1). At the molecular level, cancer is caused by mutations in DNA, which result in aberrant cell proliferation. He is currently conducting another study in which the second dose is administered three days after the first dose, before the body's production of antibodies peaks. Eventually the immune system is able to mount an attack against the mesothelioma throughout the patient's body. When the interferon gene is put into the tumor cell, the cell produces interferon into the surrounding area. Researchers are continually searching for new and better therapies that can relieve symptoms and improve the outlook for mesothelioma patients Avi Dvd Burner 2008 5 1 0 22. Avi Dvd Burner 2008 5 1 0 22 - Most of these mutations are acquired in age-dependent manner and occur in somatic (uninherited) cells. Avi Dvd Burner 2008 5 1 0 22 - These promising results encouraged Dr.  However, the researchers found that delivering two doses of the gene therapy did not provoke any more of an immune response than one dose. In the current study, the vector used was the adenovirusâ€"one of the viruses responsible for the common coldâ€"delivering a gene that carries a message for cells to produce the immune-stimulating protein, interferon Avi Dvd Burner 2008 5 1 0 22. "What we think happens is it attracts cells into the cancer, where they can recognize the cancer and develop a specific immune response against the cancer," he says. Avi Dvd Burner 2008 5 1 0 22 - So far, this approach seems to be improving the success of the gene transfer.
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